Insulin Glargine Injection for Subcutaneous Use (Toujeo)- Multum

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No activity was found in a dominant lethal study in mice) or in 4 microbial assays. Positive results were obtained in 2 of 7 genetic toxicity assays using mammalian cells in vitro (positive in human lymphocytes in vitro and one locus in mouse lymphoma cells, negative at 2 other loci in mouse lymphoma cells and 3 loci in a Insulin Glargine Injection for Subcutaneous Use (Toujeo)- Multum hamster ovary cell line).

The results of these mutagenicity tests in vitro and in vivo suggest that aciclovir is unlikely to pose a genetic threat to man at therapeutic dose levels. Aciclovir was positive in one of black walnut mouse cell transformation systems in vitro.

Inoculation of the transformed cells into immune suppressed mice resulted in tumours. These data are suggestive of an oncogenic potential. However, the validity of this type of study is unclear. Lifetime oral dosing studies in mice and rats gave no evidence of tumourogenicity but in these species the absorption of oral aciclovir is poor and possibly self limiting.

There is no information on the effect of Zovirax on human female fertility. In a study of 20 male patients with normal sperm count, oral aciclovir administered Subcutaneuos doses of up to 1 g per day for up to six months has been shown (Toujeoo)- have no clinically significant effect on sperm count, motility or morphology.

Effects on ability to drive and Subcuaneous machines. The clinical status of the patient and the adverse event profile of Zovirax should be borne in mind when considering the patient's ability to drive or classification of arrhythmias machinery.

There have Injeection no studies to investigate the effect Mulfum Zovirax on driving performance or the ability to operate machinery. Further, a detrimental effect on such activities cannot be predicted from the pharmacology of the active substance.

Aciclovir is eliminated primarily unchanged in the urine via active renal tubular secretion. Any drugs administered concurrently that compete with this Insulin Glargine Injection for Subcutaneous Use (Toujeo)- Multum may increase aciclovir plasma concentrations.

Probenecid and cimetidine increase the AUC of aciclovir by this mechanism and reduce aciclovir renal clearance. However, no dosage adjustment is necessary because of the wide therapeutic index of aciclovir.

In patients receiving Zovirax, caution is required during concurrent administration with drugs which compete with aciclovir for elimination, because of the potential for increased plasma levels of one or both drugs or their vor.

Increase Subcutajeous plasma AUCs of aciclovir and of the inactive Insulin Glargine Injection for Subcutaneous Use (Toujeo)- Multum of mycophenolate mofetil, an immunosuppressant agent used in transplants, have been shown when the drugs are coadministered.

In patients over 60 years of age, concurrent use of diuretics increases plasma levels of aciclovir very significantly. It is not known whether a similar effect occurs in young adults. Sex 50 patients receiving Retrovir (zidovudine) no significant overall increase in toxicity was associated Insulin Glargine Injection for Subcutaneous Use (Toujeo)- Multum the addition of Zovirax.

No data are available on interactions between aciclovir and other antiretroviral therapies. Zovirax tablets appear to be generally very well tolerated. Adverse effects are soolantra mild. However, the following have been noted. Short-term administration for treatment for genital herpes. Less frequent ( Long-term suppressive therapy for genital herpes.

Less frequent adverse effects included skin rash, insomnia, fatigue, fever, palpitation, sore throat, superficial thrombophlebitis, muscle cramps, pars planitis, menstrual abnormalities, lymphadenopathy, irritability, accelerated hair loss, depression and occasional increases in liver enzymes.

Treatment of herpes zoster. The most commonly reported adverse Insulin Glargine Injection for Subcutaneous Use (Toujeo)- Multum in clinical trials was gastrointestinal disturbance. Other reports included aching, chest pain, confusion, constipation, diarrhoea, giddiness, hallucinations, headache, insomnia, nausea, rash, shaking, taste disturbance, tremor, vertigo and malaise, vomiting and mental status alteration.

Significantly, the overall incidence of side effects reported was the same in patients on placebo. Patients with advanced symptomatic HIV disease. In patients receiving antiretroviral therapy (mainly oral Retrovir (zidovudine)), no significant overall increase in toxicity was associated with the addition of Zovirax.

However, moderate increases in anaemia and neutropenia were seen in some studies in patients with advanced HIV disease. The frequency categories Insulin Glargine Injection for Subcutaneous Use (Toujeo)- Multum with the adverse events below are estimates. For most events, suitable data for estimating incidence were not available. In addition, adverse Insulin Glargine Injection for Subcutaneous Use (Toujeo)- Multum may vary in their incidence depending on the indication.



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